A Clinical Trial Found an Effective Vaccine for Aggressive Breast Cancer – BlackDoctor.org
(HealthDay News) — An experimental vaccine could offer fresh hope to women diagnosed with an aggressive and hard-to-treat form of breast cancer, new research suggests.
The vaccine appears to be safe and effective against triple-negative breast cancer — a type that can’t be treated with hormone therapy because it isn’t driven by any of the three hormones that typically fuel breast cancer.
The good news? Sixteen of 18 patients remained cancer-free three years after receiving the vaccine, which taught their immune systems to kill off any remaining cancer cells, according to results published Nov. 13 in the journal Genome Medicine.
By comparison, only half of patients who receive surgery alone remain cancer-free after three years, according to historical data.
“These results were better than we expected,” said senior researcher Dr. William Gillanders, a professor of surgery at Washington University School of Medicine in St. Louis.
The early clinical trial involved 18 patients with triple-negative breast cancer that hadn’t spread elsewhere in the body.
About 10 percent to 15 percent of the breast cancers that occur in the United States are triple-negative, according to the National Breast Cancer Foundation.
To date, triple-negative breast cancer has no targeted therapies. It must be treated with traditional approaches like surgery, chemotherapy and radiation therapy, researchers said in background notes.
The trial patients all had undergone chemotherapy, followed by surgery to remove their breast tumors, researchers said.
The research team analyzed the tumor tissue following surgery to find unique genetic mutations in the patients’ cancer cells. They then crafted a personalized cancer vaccine for each patient, based on those mutations.
Each patient received three doses of the vaccine, which taught their immune systems to recognize the key mutations in their specific breast tumors and attack the cancer cells, the researchers said.
Results showed that 14 out of the 18 patients with triple-negative breast cancer developed an immune response to the vaccine.
“We are excited about the promise of these neo-antigen vaccines,” Gillanders said. “We are hopeful that we will be able to bring more and more of this type of vaccine technology to our patients and help improve treatment outcomes in patients with aggressive cancers.”
However, researchers warned that larger clinical trials are needed to prove the vaccine’s effectiveness.
“We acknowledge the limitations of this type of analysis, but we are continuing to pursue this vaccine strategy and have ongoing randomized controlled trials that do make a direct comparison between the standard of care plus a vaccine, versus standard of care alone,” Gillanders said. “We are encouraged by what we’re seeing with these patients so far.”
How does triple-negative breast cancer affect Black women?
Triple-negative breast cancer (TNBC) disproportionately affects Black women, leading to poorer outcomes compared to White women. Here’s a breakdown of the key factors:
Higher Incidence:
- Black women are nearly three times more likely to be diagnosed with TNBC compared to White women.
- This risk is particularly elevated in younger Black women and those with dense breast tissue.
Worse Outcomes:
- Black women with TNBC have higher mortality rates than White women with the same diagnosis.
- They are more likely to be diagnosed at later stages, limiting treatment options.
- Even at similar stages, Black women tend to have poorer survival rates.
Contributing Factors:
- Biological Differences: Genetic factors may play a role, although research is ongoing.
- Socioeconomic Disparities:
- Limited access to quality healthcare and screenings
- Lower socioeconomic status
- Health insurance disparities
- Transportation barriers
- Racial Bias in Healthcare:
- Implicit bias can lead to disparities in diagnosis, treatment, and care.
Importance of Early Detection and Treatment:
- Regular mammograms and clinical breast exams are crucial for early detection.
- Prompt and aggressive treatment is essential for better outcomes.
- Clinical trials are exploring targeted therapies and immunotherapies for TNBC.
Addressing Disparities:
- Increased research funding to study TNBC in Black women
- Improved access to healthcare and screenings
- Addressing racial bias in healthcare
- Patient advocacy and support groups
It’s important to note that while these disparities exist, early detection and appropriate treatment can significantly improve outcomes for Black women with TNBC.
More information
The National Breast Cancer Foundation has more on triple-negative breast cancer.
SOURCE: Washington University School of Medicine, news release, Nov. 13, 2024
